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RV-8451, differentiated oral, muscle-preserving GLP-1 candidate for obesity Recent Highlights: In February 2026, Rivus stated it was entering a pivotal year, advancing HU6 in the AMPLIFY Phase 2 MASH trial while preparing the first clinical trial for RV-8451, its muscle-preserving oral GLP-1 candidate, designed to address the muscle-loss criticism leveled at existing GLP-1 therapies

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I'm excited and proud of our cutting-edge formulation that uses both clinically-studied and patented ingredients to increase GLP-1 levels in the body, naturally." says Lemme founder Kourtney Kardashian Barker